RNA-Binding Protein Dnd1 Inhibits MicroRNA Access to Target mRNA

  title={RNA-Binding Protein Dnd1 Inhibits MicroRNA Access to Target mRNA},
  author={Martijn Kedde and Markus J. Strasser and Bijan Boldajipour and Joachim A. F. Oude Vrielink and Krasimir Slanchev and Carlos le Sage and Remco Nagel and Pieter Mathijs Voorhoeve and Josyanne van Duijse and Ulf Andersson Vang \Orom and Anders Henrik Lund and Anastassis Perrakis and Erez Raz and Reuven Agami},
MicroRNAs (miRNAs) are inhibitors of gene expression capable of controlling processes in normal development and cancer. In mammals, miRNAs use a seed sequence of 6-8 nucleotides (nt) to associate with 3' untranslated regions (3'UTRs) of mRNAs and inhibit their expression. Intriguingly, occasionally not only the miRNA-targeting site but also sequences in its vicinity are highly conserved throughout evolution. We therefore hypothesized that conserved regions in mRNAs may serve as docking… CONTINUE READING
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