RNA 3D structure prediction by using a coarse-grained model and experimental data.

@article{Xia2013RNA3S,
  title={RNA 3D structure prediction by using a coarse-grained model and experimental data.},
  author={Zhen Xia and David R. Bell and Yue Shi and Pengyu Ren},
  journal={The journal of physical chemistry. B},
  year={2013},
  volume={117 11},
  pages={3135-44}
}
RNAs form complex secondary and three-dimensional structures, and their biological functions highly rely on their structures and dynamics. Here we developed a general coarse-grained framework for RNA 3D structure prediction. A new, hybrid coarse-grained model that explicitly describes the electrostatics and hydrogen-bond interactions has been constructed based on experimental structural statistics. With the simulated annealing simulation protocol, several RNAs of less than 30-nt were folded to… CONTINUE READING