RNA (E6 and E7) assays versus DNA (E6 and E7) assays for risk evaluation for women infected with human papillomavirus.

@article{Cattani2009RNAA,
  title={RNA (E6 and E7) assays versus DNA (E6 and E7) assays for risk evaluation for women infected with human papillomavirus.},
  author={Paola Cattani and Alessia Siddu and Sara D'onghia and Simona Marchetti and Rosaria Santangelo and Valerio Gaetano Vellone and Gian Franco Zannoni and Giovanni Fadda},
  journal={Journal of clinical microbiology},
  year={2009},
  volume={47 7},
  pages={2136-41}
}
In the majority of cases, high-risk human papillomavirus (HR HPV) infections regress spontaneously, with only a small percentage progressing to high-grade lesions. Current screening methods are based on DNA detection. An alternative would be to monitor expression of the E6 and E7 viral oncogenes continuously expressed by malignant phenotypes. In the work reported in this paper, we compared the two methods for a group of women with high-risk HPV infections. Cervical specimens from 400 women… CONTINUE READING

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