RNA: prebiotic product, or biotic invention?

  title={RNA: prebiotic product, or biotic invention?},
  author={Carole Anastasi and Fabien F Buchet and Michael A Crowe and Alastair L Parkes and Matthew W Powner and James M Smith and John D Sutherland},
  journal={Chemistry & biodiversity},
  volume={4 4},
Spectacular advances in structural and molecular biology have added support to the 'RNA world' hypothesis, and provide a mandate for chemistry to explain how RNA might have been generated prebiotically on the early earth. Difficulties in achieving a prebiotically plausible synthesis of RNA, however, have led many to ponder the question posed in the title of this paper. Herein, we review recent experimental work on the assembly of potential RNA precursors, focusing on methods for stereoselective… CONTINUE READING

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View 8 Excerpts
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Journal of Molecular Evolution • 2014
View 2 Excerpts


Publications referenced by this paper.
Showing 1-6 of 6 references


P. S. Pallan, C. J. Wilds, +3 authors M. Egli
Chem., Int. Ed. 2003, 42, 5893. Received August 21, 2006 CHEMISTRY & BIODIVERSITY – Vol. 4 • 2007
View 1 Excerpt

ChemBioChem 2003

A.-A. Ingar, R.W.A. Luke, B. R. Hayter, J. D. Sutherland
4, 504. Fig. 17. RNA as a prebiotic product. An alternative scenario to that presented in Fig. 1, and one which cannot be ruled out until the complete constitutional self-assembly chemical space of RNA has been exhaustively explored. CHEMISTRY & BIODIVERSITY – Vol. 4 • 2007
View 1 Excerpt

1Prospects for Understanding the Origin of the RNAWorld2

G. F. Joyce, L. E. Orgel
1The RNA World2, 2nd edn., Eds. R. F. Gesteland, T. R. Cech, J. F. Atkins, Cold Spring Harbor Laboratory Press, Cold Spring Harbor • 1999
View 1 Excerpt

Biochemistry 1975 , 14 , 4348

M. A. Crowe, M. W. Powner, +11 authors K. Brabham
J . Am . Chem . Soc . • 1984

ChemBioChem 2005

J. M. Smith, J. D. Sutherland
6 • 1980
View 2 Excerpts


M. S. Verlander, R. Lohrmann, L. E. Orgel, J. Mol
1973, 2, 303; M. S. Verlander, L. E. Orgel, J. Mol. Evol. 1974, 3, 115; M. Renz, R. Lohrmann, L. E. Orgel, Biochim. Biophys. Acta 1971, 240, 463; D. A. Usher, A. H. McHale, Proc. Natl. Acad. Sci. U.S.A. 1976, 73, 1149; M. Bolli, R. Micura, S. Pitsch, A. Eschenmoser, Helv. Chim. Acta 1997, 80 • 1901
View 1 Excerpt

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