RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex.

@article{Chang2005RMI1NCE4AS,
  title={RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex.},
  author={Michael B. Chang and Mohammed El Bellaoui and Chaoying Zhang and Ridhdhi Desai and P. Morozov and Lissette Delgado-Cruzata and Rodney Rothstein and Greg A. Freyer and Charles Boone and Grant W Brown},
  journal={The EMBO journal},
  year={2005},
  volume={24 11},
  pages={2024-33}
}
SGS1 encodes a DNA helicase whose homologues in human cells include the BLM, WRN, and RECQ4 genes, mutations in which lead to cancer-predisposition syndromes. Clustering of synthetic genetic interactions identified by large-scale genetic network analysis revealed that the genetic interaction profile of the gene RMI1 (RecQ-mediated genome instability, also known as NCE4 and YPL024W) was highly similar to that of SGS1 and TOP3, suggesting a functional relationship between Rmi1 and the Sgs1/Top3… CONTINUE READING
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