RMA/S cells present endogenously synthesized cytosolic proteins to class I-restricted cytotoxic T lymphocytes

@article{Esquivel1992RMASCP,
  title={RMA/S cells present endogenously synthesized cytosolic proteins to class I-restricted cytotoxic T lymphocytes},
  author={Frank Esquivel and Jonathan W. Yewdell and Jack R. Bennink},
  journal={The Journal of Experimental Medicine},
  year={1992},
  volume={175},
  pages={163 - 168}
}
RMA/S is a mutant cell line with decreased cell surface expression of major histocompatibility complex class I molecules that has been reported to be deficient in presenting endogenously synthesized influenza virus nucleoprotein (NP) to cytotoxic T lymphocytes (CTL). In the present study we show that RMA/S cells can present vesicular stomatitis virus nucleocapsid protein, and, under some conditions, NP, to Kb-and Db-restricted CTL, respectively. Antigen presentation results from processing of… CONTINUE READING