RLS relieved by tobacco chewing: paradoxical role of nicotine

Abstract

Restless leg syndrome (RLS) is a sensorimotor disorder manifested as an urge to move legs which is alleviated by movement [1, 2]. It is more common in females, elderly and is a common cause of sleep disturbance [1]. The pathogenesis of RLS is unclear; however, the alleviation of RLS with dopaminergic drugs implicates D2 receptors [2]. Caffeine, nicotine and… (More)
DOI: 10.1007/s10072-011-0882-z

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