RLIP76, a non-ABC transporter, and drug resistance in epilepsy

@article{Awasthi2005RLIP76AN,
  title={RLIP76, a non-ABC transporter, and drug resistance in epilepsy},
  author={S. Awasthi and K. Hallene and V. Fazio and S. Singhal and L. Cucullo and Y. Awasthi and Gabriele Dini and D. Janigro},
  journal={BMC Neuroscience},
  year={2005},
  volume={6},
  pages={61 - 61}
}
BackgroundPermeability of the blood-brain barrier is one of the factors determining the bioavailability of therapeutic drugs and resistance to chemically different antiepileptic drugs is a consequence of decreased intracerebral accumulation. The ABC transporters, particularly P-glycoprotein, are known to play a role in antiepileptic drug extrusion, but are not by themselves sufficient to fully explain the phenomenon of drug-resistant epilepsy. Proteomic analyses of membrane protein… Expand
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