RK-1355A and B, novel quinomycin derivatives isolated from a microbial metabolites fraction library based on NPPlot screening

@article{Lim2014RK1355AAB,
  title={RK-1355A and B, novel quinomycin derivatives isolated from a microbial metabolites fraction library based on NPPlot screening},
  author={Chung Liang Lim and Toshihiko Nogawa and Masakazu Uramoto and Akiko Okano and Yayoi Hongo and Takemichi Nakamura and Hiroyuki Koshino and Shunji Takahashi and Darah Ibrahim and Hiroyuki Osada},
  journal={The Journal of Antibiotics},
  year={2014},
  volume={67},
  pages={323-329}
}
Two novel quinomycin derivatives, RK-1355A (1) and B (2), and one known quinomycin derivative, UK-63,598 (3), were isolated from a microbial metabolites fraction library of Streptomyces sp. RK88-1355 based on Natural Products Plot screening. The structural elucidation of 1 and 2 was established through two-dimensional NMR and mass spectrometric measurements. They belong to a class of quinomycin antibiotics family having 3-hydroxyquinaldic acid and a sulfoxide moiety. They are the first examples… 
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