RITA--Registry of Industrial Toxicology Animal data: the application of historical control data for Leydig cell tumors in rats.

@article{Nolte2011RITARegistryOI,
  title={RITA--Registry of Industrial Toxicology Animal data: the application of historical control data for Leydig cell tumors in rats.},
  author={Thomas Nolte and Susanne Rittinghausen and Rupert Kellner and Eberhard Karbe and Birgit Kittel and Matthias Rinke and Ulrich Deschl},
  journal={Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie},
  year={2011},
  volume={63 7-8},
  pages={645-56}
}
Historical data for Leydig cell tumors from untreated or vehicle treated rats from carcinogenicity studies collected in the RITA database are presented. Examples are given for analyses of these data for dependency on variables considered to be of possible influence on the spontaneous incidence of Leydig cell tumors. In the 7453 male rats available for analysis, only one case of a Leydig cell carcinoma was identified. The incidence of Leydig cell adenomas differed markedly between strains. High… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Year of study

  • Van Zwieten
  • Deschl et al
  • 1988
Highly Influential
7 Excerpts

Historical control data on non-neoplastic and neoplastic lesions in F344/DuCrj rats

  • H Iwata, Y Hirouchi, +5 authors M. Enomoto
  • J Toxicol Pathol
  • 1991
Highly Influential
1 Excerpt

Spontaneous neoplastic lesions in the CDF (F344) CrlBr rat

  • PL Lang
  • Raleigh: Charles River Laboratory;
  • 1990
Highly Influential
1 Excerpt

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