RISK FACTORS FOR KAPOSI'S SARCOMA IN HOMOSEXUAL MEN

@article{Marmor1982RISKFF,
  title={RISK FACTORS FOR KAPOSI'S SARCOMA IN HOMOSEXUAL MEN},
  author={Michael Marmor and LindaJ. Laubenstein and Daniel C. William and Alvin E. Friedman-kien and R.David Byrum and Sam D'Onofrio and Neil Dubin},
  journal={The Lancet},
  year={1982},
  volume={319},
  pages={1083-1087}
}
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235 Citations
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235 Citations

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National case-control study of Kaposi's sarcoma and Pneumocystis carinii pneumonia in homosexual men: Part 1. Epidemiologic results.
TLDR
Certain aspects of a lifestyle shared by a subgroup of the male homosexual population are associated with an increased risk of Kaposi's sarcoma and pneumocystis pneumonia.
Kaposi's sarcoma in homosexual men. A seroepidemiologic case-control study.
TLDR
Logistic regression analysis comparing patients with controls showed significant relative risks for Kaposi's sarcoma associated with the number of partners per month in receptive anal-genital intercourse, occasions per month of " fisting ," and cytomegalovirus antibody titers.
Generalized lymphadenopathy in homosexual men.
TLDR
It is suggested that generalized lymphadenopathy is part of the spectrum of a disorder manifested by acquired immunodeficiency, opportunistic infections, Kaposi's sarcoma, and malignant lymphomas.
Kaposi's sarcoma and malignant lymphoma in AIDS
TLDR
A 48-year-old homosexual with contacts in different countries, including Haiti, presented with multiple pigmented or bluish nodules on both lower legs and upper arms and Autopsy revealed a Kaposi's sarcoma of the skin with metastases in the stomach and a wide-spread malignant lymphoma in the gastrointestinal tract, in several visceral organs and in many lymph nodes.
Follow-up at 41/2 years on homosexual men with generalized lymphadenopathy.
TLDR
Findings suggest that nitrate inhalants may act alone or in combination with other as yet unidentified cofactors after AIDS retrovirus-induced immunodeficiency by promoting the specific disease manifestation of Kaposis sarcoma.
A surgical oncology perspective on AIDS.
TLDR
The distribution and transmission of AIDS parallels hepatitis B virus infection which is transmitted sexually and parenterally, and the same precautions as for hepatitis B should be taken for AIDS.
Kaposi's Sarcoma
TLDR
This epidemic of KS has sparked new invesligalions into the etiology and pathophysiology of KS, which have added to the knowledge of the pathogenesis of cancer.
Kaposi's sarcoma: aetiopathogenesis, histology and clinical features
TLDR
The identification of the aetiopathogenetic mechanisms (viral agents and immunodeficiency) involved in the pathogenesis of KS, are relevant for identifying susceptible subjects (HHV‐8 seropositive subjects), monitoring the immune levels in iatrogenic immune suppressed patients, and developing new therapeutic approaches based on antiviral and immune modulators.
Possible correlation between exposure to aids risk factors, clinical presentation in aids, and subsequent prognosis
TLDR
This study found that cases with opportunistic infections - that is, with a poor prognosis — had been exposed to AIDS-related risk factors at higher levels than cases with Kaposi's sarcoma alone, suggesting that the prognosis of AIDS could be associated with the level of exposure to AIDS risk factors or cofactors.
Low T-lymphocyte ratios in homosexual men. Epidemiologic evidence for a transmissible agent.
TLDR
The hypothesis that a transmissible biologic agent may be etiologically responsible for the low helper/suppressor ratios in homosexual men is supported.
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References

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TLDR
Findings indicate that physicians should be alert for Kaposis sarcoma Pneumocystis pneumonia and other opportunistic infections associated with immunosuppression in homosexual men.
AMYL NITRITE MAY ALTER T LYMPHOCYTES IN HOMOSEXUAL MEN
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TLDR
Four homosexual men presented with gradually enlarging perianal ulcers, from which herpes simplex virus was cultured, and were found to have depressed cell-mediated immunity, as evidenced by skin anergy, lymphopenia, and poor or absent responses to plant lectins and antigens in vitro.
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TLDR
The exceptionally high rate of prevalence of intestinal protozoal infection in this population of high-risk, sexually active homosexual men suggests that enteric protozoa infections arc important among sexually transmitted diseases.
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TLDR
The data suggest that sexual transmission is an important mode of spread of CMV among adults and the homosexual men are at greater risk for CMV infections than are heterosexual men.
Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency.
TLDR
Analysis of peripheral-blood T-cell subpopulations suggested that cytomegalovirus infection was an important factor in the pathogenesis of the immunodeficient state.
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TLDR
Number of different lifetime sexual partners best predicted histories of symphilis, gonorrhea, and the other diseases; frequency of checkups, years as a practicing homosexual, and furtive sexual activities were among the many other significant correlates of venereal infections.
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This study compared prevalence rates of most common sexually transmitted diseases (STD) in heterosexual and homosexual men who made respectively 12,201 and 5324 visits to an STD clinic over 18…
An outbreak of community-acquired Pneumocystis carinii pneumonia: initial manifestation of cellular immune dysfunction.
TLDR
Eleven cases of community-acquired Pneumocystis carinii pneumonia occurred between 1979 and 1981 and prompted clinical and immunologic evaluation of the patients, indicating that these groups may be at high risk for this infection.
Kaposi's sarcoma and its relationship to cytomegalovirus (CMV) III. CMV DNA and CMV early antigens in Kaposi's sarcoma
TLDR
CMV‐related antigens, mainly localized in the nucleus, were found in cryostat sections of seven of 31 tumor biopsies and four of 12 KS cell lines at early passage level, indicating that the antigen is present in a high number of tumor cells, like the Epstein‐Barr virus nuclear antigen in EBV‐transformed cells.
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