RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis

@article{Orozco2014RIPK1BP,
  title={RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis},
  author={Susana Orozco and Nader Yatim and Martin Werner and Hoanh Tran and S Y Gunja and Stephen W G Tait and Matthew L Albert and Douglas R Green and Andrew Oberst},
  journal={Cell Death and Differentiation},
  year={2014},
  volume={21},
  pages={1511-1521}
}
Necroptosis is a form of programmed cell death that depends on the activation of receptor interacting protein kinase-1 (RIPK1) and RIPK3 by receptors such as tumor necrosis factor (TNF) receptor-1. Structural studies indicate that activation of RIPK3 by RIPK1 involves the formation of oligomers via interactions of the RIP homotypic interaction motif (RHIM) domains shared by both proteins; however, the molecular mechanisms by which this occurs are not fully understood. To gain insight into this… CONTINUE READING
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Distinct roles of RIP1–RIP3 hetero- and RIP3–RIP3 homo-interaction in mediating necroptosis

  • Wu X-N, Yang Z-H, Wang X-K, Y Zhang, H Wan, Y Song
  • Cell Death Differ
  • 2014

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