RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis

@article{Loeder2012RIP1IR,
  title={RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis},
  author={Sandra Loeder and Melanie Schirmer and Hannah Schoeneberger and Silvia Cristofanon and Johannes Leibacher and Nele Vanlangenakker and Mathieu M J Bertrand and Peter Vandenabeele and Irmela Jeremias and K. M. Debatin and Simone Fulda},
  journal={Leukemia},
  year={2012},
  volume={26},
  pages={1020-1029}
}
Evasion of apoptosis may contribute to poor treatment response in pediatric acute lymphoblastic leukemia (ALL), calling for novel treatment strategies. Here, we report that inhibitors of apoptosis (IAPs) at subtoxic concentrations cooperate with various anticancer drugs (that is, AraC, Gemcitabine, Cyclophosphamide, Doxorubicin, Etoposide, Vincristine and Taxol) to induce apoptosis in ALL cells in a synergistic manner as calculated by combination index and to reduce long-term clonogenic… CONTINUE READING