RIP Kinase-Mediated Necrosis as an Alternative Mechanism of Photoreceptor Death

@inproceedings{Murakami2011RIPKN,
  title={RIP Kinase-Mediated Necrosis as an Alternative Mechanism of Photoreceptor Death},
  author={Yusuke Murakami and Joan W Miller and Demetrios G Vavvas},
  booktitle={Oncotarget},
  year={2011}
}
Photoreceptor cell death is the terminal event in a variety of retinal disorders including age-related macular degeneration, retinitis pigmentosa, and retinal detachment. Apoptosis has been thought to be the major form of cell death in these diseases, however accumulating evidence suggests that another pathway, programmed necrosis is also important. Recent studies have shown that, when caspase pathways are blocked, receptor interacting protein (RIP) kinases promote necrosis and overcome… CONTINUE READING

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