RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1.

Abstract

BACKGROUND RNF168 promotes chromosomal break localization of 53BP1 and BRCA1; 53BP1 loss rescues homologous recombination (HR) in BRCA1-deficient cells. RESULTS RNF168 depletion suppresses HR defects caused by BRCA1 silencing; RNF168 influences HR similarly to 53BP1. CONCLUSION RNF168 is important for HR defects caused by BRCA1 loss. SIGNIFICANCE… (More)
DOI: 10.1074/jbc.M112.410951

Topics

Cite this paper

@article{Muoz2012RINGFN, title={RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1.}, author={Meilen C. Mu{\~n}oz and Corentin Laulier and Amanda Gunn and Anita Cheng and Davide F Robbiani and Andr{\'e} Nussenzweig and Jeremy M. Stark}, journal={The Journal of biological chemistry}, year={2012}, volume={287 48}, pages={40618-28} }