RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPA-mediated DNA damage response.

@article{Liu2011RINGFA,
  title={RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPA-mediated DNA damage response.},
  author={Shang-feng Liu and Jessica H. Chu and Nur Yucer and Mei Chen Leng and S Wang and Benjamin Ping-Chi Chen and Walter N. Hittelman and Yi Ke Wang},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 25},
  pages={22314-22}
}
DNA damage response is crucial for maintaining genomic integrity and preventing cancer by coordinating the activation of checkpoints and the repair of damaged DNA. Central to DNA damage response are the two checkpoint kinases ATM and ATR that phosphorylate a wide range of substrates. RING finger and WD repeat domain 3 (RFWD3) was initially identified as a substrate of ATM/ATR from a proteomic screen. Subsequent studies showed that RFWD3 is an E3 ubiquitin ligase that ubiquitinates p53 in vitro… CONTINUE READING