RIN1 regulates cell migration through RAB5 GTPases and ABL tyrosine kinases

@inproceedings{Balaji2013RIN1RC,
  title={RIN1 regulates cell migration through RAB5 GTPases and ABL tyrosine kinases},
  author={Kavitha Balaji and John Colicelli},
  booktitle={Communicative & integrative biology},
  year={2013}
}
Stimulation of a receptor tyrosine kinase (RTK), such as EGFR, leads to RAS activation followed by RIN1 activation. RIN1, in turn, activates RAB5 family GTPases, as well as ABL tyrosine kinases. As expected, RIN1 expression directly correlates with RAB5-mediated EGFR endocytosis. We previously showed that normal receptor endocytosis and internalized EGFR… CONTINUE READING