RIMA — A new concept in the treatment of depression with moclobemide

  title={RIMA — A new concept in the treatment of depression with moclobemide},
  author={R. Amrein and W. D. Hetzel and Max Stabl and W. Schmid-burgk},
  journal={International Clinical Psychopharmacology},
Moclobemide, a specific reversible inhibitor of monoamine oxidase that shows a preference for the A isoenzyme, has been developed as a new antidepressive agent. Unlike earlier generation monoamine oxidase inhibitors, moclobemide is devoid of any clinically significant tyramine interaction, thus making dietary restrictions during therapy unnecessary. In comparative trials, moclobemide has been found to be superior to placebo and similar to imipramine, clomipramine, and amitriptyline in clinical… Expand
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No difference in antidepressive efficacy between the two drugs, but imipramine had more anticholinergic side-effects and neither drug had significant effects on pulse rate, blood pressure, weight changes or blood chemistry. Expand
A Risk-Benefit Assessment of Moclobemide in the Treatment of Depressive Disorders
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Clinical pharmacology of MAO inhibitors: safety and future.
It seems obvious that a greater understanding of the pharmacodynamics and pharmacokinetics of MAOIs could result in improved treatment of the patients in the future, and selective MAO-B inhibitors and RIMAs hold promise as safer alternatives to classicalMAOIs. Expand
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Moclobemide in continuation treatment of major depressive episodes: an open follow-up study over six months.
Moclobemide as continuation treatment of patients with major depressive episodes and comorbid anxiety was efficacious over a 6-month period, and there was some additional antidepressant effect after 6 weeks of acute treatment. Expand
Comparison of the effects of moclobemide and selegiline on tyramine-evoked mydriasis in man.
The potentiation of tyramine-evoked mydriasis by moclobemide is likely to reflect the inhibition of MAO-A activity in the iris, consistent with the activity of this enzyme in sympathetic nerve terminals. Expand
Double‐blind randomized controlled study of the efficacy and tolerability of two reversible monoamine oxidase A inhibitors, pirlindole and moclobemide, in the treatment of depression
The differences between the two drugs were non‐significant for all types of side‐effect, with the exception of dry mouth and tachycardia, which were significantly more frequent with moclobemide. Expand
A comparison of the efficacy and tolerability of moclobemide given as a single daily dose or in three divided doses per day for the treatment of patients with a major depressive episode (DSM-III-R)
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