RIM proteins and their role in synapse function.

  title={RIM proteins and their role in synapse function.},
  author={Tobias Mittelstaedt and Elena Alv{\'a}rez-Bar{\'o}n and Susanne Schoch},
  journal={Biological chemistry},
  volume={391 6},
Active zones are specialized areas of the plasma membrane in the presynaptic nerve terminal that mediate neurotransmitter release and synaptic plasticity. The multidomain proteins RIM1 and RIM2 are integral components of the cytomatrix at the active zone, interacting with most other active zone-enriched proteins as well as synaptic vesicle proteins. In the brain, RIMs are present in multiple isoforms (alpha, beta, gamma) diverging in their structural composition, which mediate overlapping and… CONTINUE READING


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