RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release.

@article{Liu2011RIMbindingPA,
  title={RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release.},
  author={Karen Suk Yin Liu and Matthias Siebert and Sara Mertel and Elena Knoche and Stephanie Wegener and Carolin Wichmann and Tanja Matkovi{\'c} and Karzan Muhammad and Harald Depner and Christoph Mettke and Johanna B{\"u}ckers and Stefan W Hell and Martin Mueller and Graeme W Davis and Dietmar Schmitz and Stephan J. Sigrist},
  journal={Science},
  year={2011},
  volume={334 6062},
  pages={1565-9}
}
The molecular machinery mediating the fusion of synaptic vesicles (SVs) at presynaptic active zone (AZ) membranes has been studied in detail, and several essential components have been identified. AZ-associated protein scaffolds are viewed as only modulatory for transmission. We discovered that Drosophila Rab3-interacting molecule (RIM)-binding protein (DRBP) is essential not only for the integrity of the AZ scaffold but also for exocytotic neurotransmitter release. Two-color stimulated… CONTINUE READING
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