RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism.

@article{Ma2011RIGlikeHI,
  title={RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism.},
  author={Bing Ma and Charles S Dela Cruz and Dominik Hartl and Min-Jong Kang and Shervin S Takyar and Robert J Homer and Chun Geun Lee and Jack A Elias},
  journal={American journal of respiratory and critical care medicine},
  year={2011},
  volume={183 10},
  pages={
          1322-35
        }
}
RATIONALE Vascular endothelial growth factor (VEGF) regulates vascular, inflammatory, remodeling, and cell death responses. It plays a critical role in normal pulmonary physiology, and VEGF excess and deficiency have been implicated in the pathogenesis of asthma and chronic obstructive pulmonary disease, respectively. Although viruses are an important cause of chronic obstructive pulmonary disease exacerbations and innate responses play an important role in these exacerbations, the effects of… CONTINUE READING

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