RIG-I-mediated antiviral signaling is inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-I.

@article{Solis2011RIGImediatedAS,
  title={RIG-I-mediated antiviral signaling is inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-I.},
  author={Mayra Solis and P. Nakhaei and Mohammad Jalalirad and Judith Lacoste and Ren{\'e}e Douville and Meztli D Arguello and Tiejun Zhao and M. Laughrea and Mark A. Wainberg and John Hiscott},
  journal={Journal of virology},
  year={2011},
  volume={85 3},
  pages={1224-36}
}
The rapid induction of type I interferon (IFN) is essential for establishing innate antiviral responses. During infection, cytoplasmic viral RNA is sensed by two DExD/H box RNA helicases, RIG-I and MDA5, ultimately driving IFN production. Here, we demonstrate that purified genomic RNA from HIV-1 induces a RIG-I-dependent type I IFN response. Both the dimeric and monomeric forms of HIV-1 were sensed by RIG-I, but not MDA5, with monomeric RNA, usually found in defective HIV-1 particles, acting as… CONTINUE READING

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Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage

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