RIG-I goes beyond naked recognition.

  title={RIG-I goes beyond naked recognition.},
  author={John Bradford Bowzard and Priya Ranjan and Suryaprakash Sambhara},
  journal={Cell host & microbe},
  volume={13 3},
It is currently unclear at which point during viral replication that RNA genomes are first recognized as nonself by the immune system. In this issue of Cell Host & Microbe, Weber et al. show that incoming nucleocapsid-bound genomes are sufficient to bind and activate innate immune sensors.