RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

@article{Ablasser2009RIGIdependentSO,
  title={RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate},
  author={Andrea Ablasser and Franz Bauernfeind and Gunther Hartmann and Eicke Latz and Katherine A. Fitzgerald and V. Hornung},
  journal={Nature Immunology},
  year={2009},
  volume={10},
  pages={1065-1072}
}
RNA is sensed by Toll-like receptor 7 (TLR7) and TLR8 or by the RNA helicases LGP2, Mda5 and RIG-I to trigger antiviral responses. Much less is known about sensors for DNA. Here we identify a novel DNA-sensing pathway involving RNA polymerase III and RIG-I. In this pathway, AT-rich double-stranded DNA (dsDNA) served as a template for RNA polymerase III and was transcribed into double-stranded RNA (dsRNA) containing a 5′-triphosphate moiety. Activation of RIG-I by this dsRNA induced production… CONTINUE READING
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