RIG-I and dsRNA-Induced IFNβ Activation

@article{Hausmann2008RIGIAD,
  title={RIG-I and dsRNA-Induced IFNβ Activation},
  author={St{\'e}phane Hausmann and J B Marq and Caroline Tapparel and Daniel Kolakofsky and Dominique Garcin},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={227 - 264}
}
Except for viruses that initiate RNA synthesis with a protein primer (e.g., picornaviruses), most RNA viruses initiate RNA synthesis with an NTP, and at least some of their viral (ppp)RNAs remain unblocked during the infection. Consistent with this, most viruses require RIG-I to mount an innate immune response, whereas picornaviruses require mda-5. We have examined a SeV infection whose ability to induce interferon depends on the generation of capped dsRNA (without free 5' tri-phosphate ends… CONTINUE READING

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