RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates

@article{Pichlmair2006RIGIMediatedAR,
  title={RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates},
  author={Andreas Pichlmair and Oliver Schulz and Choon Ping Tan and Tanja I. Näslund and Peter Liljestr{\"o}m and Friedemann Weber and Caetano Reis e Sousa},
  journal={Science},
  year={2006},
  volume={314},
  pages={1001 - 997}
}
Double-stranded RNA (dsRNA) produced during viral replication is believed to be the critical trigger for activation of antiviral immunity mediated by the RNA helicase enzymes retinoic acid–inducible gene I (RIG-I) and melanoma differentiation–associated gene 5 (MDA5). We showed that influenza A virus infection does not generate dsRNA and that RIG-I is activated by viral genomic single-stranded RNA (ssRNA) bearing 5′-phosphates. This is blocked by the influenza protein nonstructured protein 1… 

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