RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell.

@article{Mao1996RIGEAH,
  title={RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell.},
  author={Mao Mao and Ming-Jiun Yu and Jeffrey H Tong and Jin Ye and Jun Zhu and Qiu Hong Huang and Gui-lian Fu and Liping Yu and Shou Yuan Zhao and Samuel Waxman and Michel Lanotte and Zhepeng Wang and Judith Zhi-Yie Tan and Shu Jin Chan and Zhu Chen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 12},
  pages={5910-4}
}
In vivo all-trans-retinoic acid (ATRA), a differentiation inducer, is capable of causing clinical remission in about 90% of patients with acute promyelocytic leukemia (APL). The molecular basis for the differentiation of APL cells after treatment with ATRA remains obscure and may involve genes other than the known retinoid nuclear transcription factors. We report here the ATRA-induced gene expression in a cell line (NB4) derived from a patient with APL. By differential display-PCR, we isolated… CONTINUE READING

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