RIFM fragrance ingredient safety assessment, Eugenol, CAS Registry Number 97-53-0.

@article{Api2016RIFMFI,
  title={RIFM fragrance ingredient safety assessment, Eugenol, CAS Registry Number 97-53-0.},
  author={Anne Marie Api and Donald V. Belsito and Sneha Bhatia and Magnus Bruze and Peter Calow and M L Dagli and Wolfgang Dekant and A D Fryer and Lambros Kromidas and Shannon La Cava and Jon F Lalko and Aurelia Lapczynski and Daniel C. Liebler and Yoshimitsu Miyachi and Valerie T. Politano and Gretchen Ritacco and Daniel T. Salvito and T. Wayne Schultz and J. Shen and I. Glenn Sipes and B. Wall and David K. Wilcox},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2016},
  volume={97S},
  pages={
          S25-S37
        }
}
  • A. Api, D. Belsito, D. K. Wilcox
  • Published 1 November 2016
  • Biology, Environmental Science
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Tables from this paper

Levels of methyleugenol and eugenol in instant herbal beverages available on the Indonesian market and related risk assessment.
Determination of fragrance allergens and their dermal sensitization quantitative risk assessment (QRA) in 107 spray perfumes
TLDR
The findings indicate that the sensitization risk of allergens with AEL:CEL ratios below 1 detected in fragrances needs to be reduced to the appropriate human safety level for risk management.
Contact allergy to fragrance mix I and its components in individuals with photocontact allergy to ketoprofen
Contact allergy to fragrance mix I (FM I) is over‐represented in patients photoallergic to ketoprofen. The prevalence of contact allergy to two components of FM I, cinnamal and cinnamyl alcohol, in
Expression and function of the ectopic olfactory receptor OR10G7 in patients with atopic dermatitis
A minireview of effects of maternal diet during pregnancy on postnatal vegetable consumption: Implications for future research (a new hypothesis) and recommendations
TLDR
Prenatal exposure to nonbitter vegetables leads to an increased vegetable consumption at early childhood in comparison to prenatal exposure to bitter vegetables, postnatal exposure to vegetables and no exposure, and the following hypothesis to be tested in the future.
Update to RIFM fragrance ingredient safety assessment, eugenol, CAS Registry Number 97-53-0.
  • A. Api, D. Belsito, Y. Tokura
  • Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2022
Synergistic Effect of Eugenol and Probiotic Lactobacillus Plantarum Zs2058 against Salmonella Infection in C57bl/6 Mice
TLDR
The obtained results suggest that ZS2058 and eugenol have a synergistic effect on preventing Salmonella infection and open new perspectives in the strategies of controlling the prevalence of Salmoneella by combination of probiotics and functional food components.
A minireview of effects of maternal diet during pregnancy on postnatal vegetable consumption: Implications for future research (a new hypothesis) and recommendations
TLDR
It is proposed here that the vegetable type used in these last studies might explain this disparity of results, and the following hypothesis to be tested in the future: prenatal exposure to nonbitter vegetables leads to an increased vegetable consumption at early childhood in comparison to prenatal Exposure to bitter vegetables, postnatal exposure to vegetables and no exposure.

References

SHOWING 1-10 OF 211 REFERENCES
Evaluation of the developmental toxicity of isoeugenol in Sprague-Dawley (CD) rats.
TLDR
The maternal toxicity lowest observed adverse effect level (LOAEL) was 250 mg/kg/day based primarily on reduced body weight and gestational weight gain (corrected for gravid uterine weight), and the maternal toxicity no observed adverseEffect level (NOAel) was not determined in this study.
A framework for prioritizing fragrance materials for aquatic risk assessment
TLDR
These combined exercises demonstrated the ability of this highly precautionary risk-based screening approach to quickly prioritize a large number of materials without benefit of experimental ecotoxicological or fate data.
Genotoxicity and endoreduplication inducing activity of the food flavouring eugenol.
TLDR
The results confirm that eugenol is genotoxic and raises the possibility of it having topoisomerase II inhibiting activity, with ICRF-193 being a more potent inhibitor.
The use of ex vivo human skin tissue for genotoxicity testing.
Food flavourings and compounds of related structure. II. Subacute and chronic toxicity.
Structure-activity relationships in the developmental toxicity of substituted phenols: in vivo effects.
TLDR
The properties of these phenolic congeners that promote maternal toxicity are different from those that contribute to developmental toxicity, and it is likely that the mechanisms of toxicity behind these effects are also different.
Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients.
  • A. Api, D. Belsito, D. K. Wilcox
  • Environmental Science
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2015
An in silico skin absorption model for fragrance materials.
  • Jie Shen, L. Kromidas, T. Schultz, S. Bhatia
  • Environmental Science
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2014
Genotoxicity of safrole-related chemicals in microbial test systems.
...
...