RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT, 2-Isobutyl-4-methyltetrahydro-2H-pyran-4-ol, CAS registry number 63500-71-0.

@article{Api2019RIFMFI,
  title={RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT, 2-Isobutyl-4-methyltetrahydro-2H-pyran-4-ol, CAS registry number 63500-71-0.},
  author={Anne Marie Api and Danielle Belsito and Delane Botelho and Magnus Bruze and G Allen Burton and Jochen Buschmann and Maria Lucia Zaidan Dagli and Masakazu Date and Wolfgang Dekant and Chaitra Deodhar and Maria Francis and Allison D Fryer and L Jones and Karan Joshi and Silvia La Cava and Aurelia Lapczynski and Daniel C. Liebler and D O'brien and Atish Patel and Trevor M Penning and Gretchen Ritacco and Jennifer Romine and N Sadekar and Daniel T Salvito and Terry Wayne Schultz and I. Glenn Sipes and Ginny Sullivan and Yash Thakkar and Y Tokura and S Tsang},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2019},
  pages={
          110564
        }
}
2-Isobutyl-4-methyltetrahydro-2H-pyran-4-ol) was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that 2-isobutyl-4-methyltetrahydro-2H-pyran-4-ol is not genotoxic, does not have skin sensitization potential, and provided an MOE >100 for the repeated dose, developmental, and reproductive toxicity endpoints. The local respiratory toxicity endpoint was… CONTINUE READING

Topics from this paper.