RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis.

@article{Inohara1998RICKAN,
  title={RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis.},
  author={Naohiro Inohara and Luis Del Peso and Takeyoshi Koseki and Sheng-hong Chen and Gabriel N{\'u}{\~n}ez},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 20},
  pages={12296-300}
}
Signaling through the CD95/Fas/APO-1 death receptor plays a critical role in the homeostasis of the immune system. RICK, a novel protein kinase that regulates CD95-mediated apoptosis was identified and characterized. RICK is composed of an N-terminal serine-threonine kinase catalytic domain and a C-terminal region containing a caspase-recruitment domain. RICK physically interacts with CLARP, a caspase-like molecule known to bind to Fas-associated protein with death domain (FADD) and caspase-8… CONTINUE READING

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