RGS4 modulates serotonin signaling in prefrontal cortex and links to serotonin dysfunction in a rat model of schizophrenia.

@article{Gu2007RGS4MS,
  title={RGS4 modulates serotonin signaling in prefrontal cortex and links to serotonin dysfunction in a rat model of schizophrenia.},
  author={Zhenglin Gu and Qian Jiang and Zhen Yan},
  journal={Molecular pharmacology},
  year={2007},
  volume={71 4},
  pages={1030-9}
}
Regulator of G protein signaling 4 (RGS4) has recently been identified as one of the genes linked to the susceptibility of schizophrenia. However, the functional roles of RGS4 and how it may be involved in the pathophysiology of schizophrenia remain largely unknown. In this study, we investigated the possible impact of RGS4 on the function of serotonin and dopamine receptors, two main targets for schizophrenia treatment. Activation of serotonin 5-HT(1A) receptors or dopamine D(4) receptors down… CONTINUE READING

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Differential effects of regulator of G protein signaling

  • KH Young
  • 2004

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