RGS4 is a negative regulator of insulin release from pancreatic beta-cells in vitro and in vivo.

@article{Azua2010RGS4IA,
  title={RGS4 is a negative regulator of insulin release from pancreatic beta-cells in vitro and in vivo.},
  author={Inigo Ruiz de Azua and Marco Scarselli and Erica Rosemond and Dinesh Ratan Gautam and William Jou and Oksana Gavrilova and Philip J. Ebert and Pat Levitt and Juergen Wess},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 17},
  pages={7999-8004}
}
Therapeutic strategies that augment insulin release from pancreatic beta-cells are considered beneficial in the treatment of type 2 diabetes. We previously demonstrated that activation of beta-cell M(3) muscarinic receptors (M3Rs) greatly promotes glucose-stimulated insulin secretion (GSIS), suggesting that strategies aimed at enhancing signaling through beta-cell M3Rs may become therapeutically useful. M3R activation leads to the stimulation of G proteins of the G(q) family, which are under… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 40 references

RGS4 controls renal blood flow and inhibits cyclosporine-mediated nephrotoxicity.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons • 2010

2009)Breast cancermigrationand invasiondependonproteasomedegradation of regulator of G-protein signaling

XieY, etal
Cancer Res • 2009

Breast cancermigrationand invasiondependonproteasomedegradation of regulator of G - protein signaling 4

SL Sandiford, VZ Slepak
Cancer Res • 2009

The organization of the transcriptional network in specific neuronal classes

KD Winden
Mol Syst Biol • 2009

Location, location, location

AB Tobin, AJ Butcher, KC Kong
Trends Pharmacol Sci 29:413–420 • 2008

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