RGS3 mediates a calcium-dependent termination of G protein signaling in sensory neurons

@article{Tosetti2003RGS3MA,
  title={RGS3 mediates a calcium-dependent termination of G protein signaling in sensory neurons},
  author={P. Tosetti and N. Pathak and M. H. Jacob and K. Dunlap},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100},
  pages={7337 - 7342}
}
  • P. Tosetti, N. Pathak, +1 author K. Dunlap
  • Published 2003
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • G proteins modulate synaptic transmission. Regulators of G protein signaling (RGS) proteins accelerate the intrinsic GTPase activity of Gα subunits, and thus terminate G protein activation. Whether RGS proteins themselves are under cellular control is not well defined, particularly in native cells. In dorsal root ganglion neurons overexpressing RGS3, we find that G protein signaling is rapidly terminated (or “desensitized”) by calcium influx through voltage-gated channels. This rapid… CONTINUE READING
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