RGS3 mediates a calcium-dependent termination of G protein signaling in sensory neurons.

@article{Tosetti2003RGS3MA,
  title={RGS3 mediates a calcium-dependent termination of G protein signaling in sensory neurons.},
  author={Patrizia Tosetti and Narendra R. Pathak and Michele H. Jacob and Kathleen Dunlap},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 12},
  pages={
          7337-42
        }
}
G proteins modulate synaptic transmission. Regulators of G protein signaling (RGS) proteins accelerate the intrinsic GTPase activity of Galpha subunits, and thus terminate G protein activation. Whether RGS proteins themselves are under cellular control is not well defined, particularly in native cells. In dorsal root ganglion neurons overexpressing RGS3, we find that G protein signaling is rapidly terminated (or "desensitized") by calcium influx through voltage-gated channels. This rapid… CONTINUE READING
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