RGS3 and RGS4 are GTPase activating proteins in the heart.

@article{Zhang1998RGS3AR,
  title={RGS3 and RGS4 are GTPase activating proteins in the heart.},
  author={Shaosong Zhang and Ned Watson and Josef Zahner and Jeffrey N. Rottman and Kendall J Blumer and Anthony J. Muslin},
  journal={Journal of molecular and cellular cardiology},
  year={1998},
  volume={30 2},
  pages={
          269-76
        }
}
RGS family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes when tested in vitro and in vivo. Although the function of RGS proteins in cardiac physiology is unknown, their ability to deactivate Galpha subunits suggests that they may inhibit the action of muscarinic, alpha-adrenergic, endothelin, and other agonists… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 34 CITATIONS

A finer tuning of G-protein signaling through regulated control of RGS proteins.

  • American journal of physiology. Heart and circulatory physiology
  • 2012
VIEW 4 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Expression of RGS3, RGS4 and Gi alpha 2 in acutely failing donor hearts and end-stage heart failure.

  • European heart journal
  • 2001
VIEW 3 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

RGS Redundancy and Implications in GPCR-GIRK Signaling.

  • International review of neurobiology
  • 2015
VIEW 2 EXCERPTS
CITES BACKGROUND