• Biology, Medicine
  • Published in Nature Neuroscience 2007
  • DOI:10.1038/nn2006

RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area

@article{Laboube2007RGS2MC,
  title={RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area},
  author={Gwena{\"e}l Labou{\`e}be and Marta Lomazzi and Hans Gabriel Cruz and Cyril Creton and Rafael Luj{\'a}n and Meng Li and Yuchio Yanagawa and Kunihiko Obata and Masahiko Watanabe and Kevin Wickman and Stephanie B Boyer and Paul A Slesinger and Christian L{\"u}scher},
  journal={Nature Neuroscience},
  year={2007},
  volume={10},
  pages={1559-1568}
}
Agonists of GABAB receptors exert a bi-directional effect on the activity of dopamine (DA) neurons of the ventral tegmental area, which can be explained by the fact that coupling between GABAB receptors and G protein-gated inwardly rectifying potassium (GIRK) channels is significantly weaker in DA neurons than in GABA neurons. Thus, low concentrations of agonists preferentially inhibit GABA neurons and thereby disinhibit DA neurons. This disinhibition might confer reinforcing properties on… CONTINUE READING

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