RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area

@article{Laboube2007RGS2MC,
  title={RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area},
  author={G. Labou{\`e}be and M. Lomazzi and Hans G Cruz and C. Creton and R. Luj{\'a}n and Meng Li and Y. Yanagawa and K. Obata and Masahiko Watanabe and K. Wickman and Stephanie B Boyer and P. Slesinger and C. L{\"u}scher},
  journal={Nature Neuroscience},
  year={2007},
  volume={10},
  pages={1559-1568}
}
Agonists of GABAB receptors exert a bi-directional effect on the activity of dopamine (DA) neurons of the ventral tegmental area, which can be explained by the fact that coupling between GABAB receptors and G protein-gated inwardly rectifying potassium (GIRK) channels is significantly weaker in DA neurons than in GABA neurons. Thus, low concentrations of agonists preferentially inhibit GABA neurons and thereby disinhibit DA neurons. This disinhibition might confer reinforcing properties on… Expand
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