• DOI:10.1182/BLOOD-2004-03-0940
Corpus ID: 1042664

RGS2 is an important target gene of Flt3-ITD mutations in AML and functions in myeloid differentiation and leukemic transformation.

@article{Schwaeble2005RGS2IA,
  title={RGS2 is an important target gene of Flt3-ITD mutations in AML and functions in myeloid differentiation and leukemic transformation.},
  author={J. Schwaeble and C. Choudhary and C. Thiede and L. Tickenbrock and B. Sargin and C. Steur and M. Rehage and A. Rudat and C. Brandts and W. Berdel and C. M{\"u}ller-Tidow and H. Serve},
  journal={Blood},
  year={2005},
  volume={105 5},
  pages={
          2107-14
        }
}

J. Schwaeble, C. Choudhary, +9 authors H. Serve

Published 2005

Biology, Medicine

Blood

Activating fetal liver tyrosine kinase 3 (Flt3) mutations represent the most common genetic aberrations in acute myeloid leukemia (AML). Most commonly, they occur as internal tandem duplications in the juxtamembrane domain (Flt3-ITD) that transform myeloid cells in vitro and in vivo and that induce aberrant signaling and biologic functions. We identified RGS2, a regulator of G-protein signaling, as a gene specifically repressed by Flt3-ITD. Here we demonstrate an important role of RGS2 in Flt3… CONTINUE READING

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