RGS2 blocks slow muscarinic inhibition of N-type Ca(2+) channels reconstituted in a human cell line.

@article{Melliti2001RGS2BS,
  title={RGS2 blocks slow muscarinic inhibition of N-type Ca(2+) channels reconstituted in a human cell line.},
  author={Karim Melliti and Ulises Meza and Brett A. Adams},
  journal={The Journal of physiology},
  year={2001},
  volume={532 Pt 2},
  pages={337-47}
}
1. Native N-type Ca(2+) channels undergo sustained inhibition through a slowly activating pathway linked to M1 muscarinic acetylcholine receptors and Galphaq/11 proteins. Little is known concerning the regulation of this slow inhibitory pathway. We have reconstituted slow muscarinic inhibition of N-type channels in HEK293 cells (a human embryonic kidney cell line) by coexpressing cloned alpha1B (Ca(V)2.2) Ca(2+) channel subunits and M1 receptors. Expressed Ca(2+) currents were recorded using… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…