RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acid-sensing OGR1/NFAT signaling pathway.

@article{Iwai2007RGS18AA,
  title={RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acid-sensing OGR1/NFAT signaling pathway.},
  author={Kaori Iwai and Masato Koike and Shiro Ohshima and Kunio Miyatake and Yasuo Uchiyama and Yukihiko Saeki and Masaru Ishii},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2007},
  volume={22 10},
  pages={1612-20}
}
UNLABELLED We showed that RGS18, a myeloid lineage-specific RGS protein that is inhibited after activation of the RANK/RANKL system, is a negative regulator of osteoclastogenesis. RGS18 acts through an external acidosis-sensing osteoclastogenic mechanism through the OGR1/NFAT pathway. INTRODUCTION Osteoclasts are bone-resorbing multinuclear giant cells that are differentiated from mononuclear macrophage/monocyte lineage precursors stimulated by the RANK/RANKL system. The regulators of G… CONTINUE READING
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