RGS16 inhibits signalling through the Gα13–Rho axis

  title={RGS16 inhibits signalling through the Gα13–Rho axis},
  author={E. Johnson and T. M. Seasholtz and A. Waheed and Barry Kreutz and Nobuchika Suzuki and T. Kozasa and T. L. Jones and J. Brown and K. Druey},
  journal={Nature Cell Biology},
  • E. Johnson, T. M. Seasholtz, +6 authors K. Druey
  • Published 2003
  • Biology
  • Nature Cell Biology
  • Gα13 stimulates the guanine nucleotide exchange factors (GEFs) for Rho, such as p115Rho-GEF. Activated Rho induces numerous cellular responses, including actin polymerization, serum response element (SRE)-dependent gene transcription and transformation. p115Rho-GEF contains a Regulator of G protein Signalling domain (RGS box) that confers GTPase activating protein (GAP) activity towards Gα12 and Gα13 (ref. 3). In contrast, classical RGS proteins (such as RGS16 and RGS4) exhibit RGS domain… CONTINUE READING
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