RGS16 inhibits signalling through the Gα13–Rho axis

@article{Johnson2003RGS16IS,
  title={RGS16 inhibits signalling through the G$\alpha$13–Rho axis},
  author={Eric N. Johnson and Tammy M. Seasholtz and Abdul A. Waheed and Barry Kreutz and Nobuchika Suzuki and Tohru Kozasa and Teresa L. Z. Jones and Joan Heller Brown and Kirk M. Druey},
  journal={Nature Cell Biology},
  year={2003},
  volume={5},
  pages={1095-1103}
}
Gα13 stimulates the guanine nucleotide exchange factors (GEFs) for Rho, such as p115Rho-GEF. Activated Rho induces numerous cellular responses, including actin polymerization, serum response element (SRE)-dependent gene transcription and transformation. p115Rho-GEF contains a Regulator of G protein Signalling domain (RGS box) that confers GTPase activating protein (GAP) activity towards Gα12 and Gα13 (ref. 3). In contrast, classical RGS proteins (such as RGS16 and RGS4) exhibit RGS domain… 
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TLDR
The use of specific RGS domain constructs to discriminate among G(i/o), Gq-and G(12/13)-mediated activation of phospholipase C (PLC) isozymes in COS-7 cells is described.
R4 RGS proteins: regulation of G-protein signaling and beyond.
TLDR
This review highlights recent advances in the understanding of the physiological functions of one subfamily of RGS proteins with a high degree of homology (B/R4) gleaned from recent studies of knockout mice or cells with reduced RGS expression.
Regulation of RhoGEF proteins by G12/13‐coupled receptors
  • S. Siehler
  • Biology, Medicine
    British journal of pharmacology
  • 2009
TLDR
An overview of G 12/13 signalling of GPCRs with a focus on RhoGEF proteins as the immediate mediators of G12/13 activation is given, which provides novel therapeutic approaches for cancer, cardiovascular diseases, arterial and pulmonary hypertension, and bronchial asthma.
Multi-tasking RGS proteins in the heart: the next therapeutic target?
TLDR
RGS proteins are regulators of cardiovascular physiology and potentially novel drug targets as well because of the importance of GPCR-signaling pathways and the profound influence of RGS proteins on these pathways.
Gα13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis
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It is shown that myocyte-specific enhancer factor-2 (MEF2) mediates G α13-dependent angiogenesis and that MEF2 proteins are an important component in Gα13-mediatedAngiogenesis.
The superfamily of "regulator of g-protein signaling" (rgs) proteins
TLDR
A large family of seven transmembrane-domain receptors for hormones, neurotransmitters, growth factors, chemoattractants, light, odorants, and other extracellular stimuli promote intracellular signaling responses by activation of heterotrimeric G proteins, which include additional functionalities beyond their hallmark capacity to act as GAPs for Gα subunits.
Regulators of G-protein-signaling proteins: negative modulators of G-protein-coupled receptor signaling.
TLDR
Human and animal studies have revealed that RGS proteins play a vital role in physiology and can be ideal targets for diseases such as those related to addiction where receptor signaling seems continuously switched on.
Protein kinase inhibitor β enhances the constitutive activity of G-protein-coupled zinc receptor GPR39.
TLDR
Mutation of this domain abolished the inhibitory activity of PKIB on protein kinase A activity, but had no effect on the interaction with GPR39, cell protection and induction of SRE-dependent transcription.
Regulator of G‐Protein Signaling 16 Is a Negative Modulator of Platelet Function and Thrombosis
TLDR
A critical role for R GS16 in regulating hemostatic and thrombotic functions of platelets in mice is supported and RGS16 represents a potential therapeutic target for modulating platelet function.
G12/13-dependent signaling of G-protein-coupled receptors: disease context and impact on drug discovery
  • S. Siehler
  • Biology, Medicine
    Expert opinion on drug discovery
  • 2007
TLDR
The review gives an overview of the present understanding of the G12/13-related biology of GPCR and finds many GPCRs were found to couple to G 12/13 proteins in addition to coupling to one or more other types of G proteins.
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