RGS16 inhibits breast cancer cell growth by mitigating phosphatidylinositol 3-kinase signaling.

@article{Liang2009RGS16IB,
  title={RGS16 inhibits breast cancer cell growth by mitigating phosphatidylinositol 3-kinase signaling.},
  author={Genqing Liang and Geetanjali Bansal and Zhihui Xie and Kirk M. Druey},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 32},
  pages={21719-27}
}
Aberrant activity of the phosphatidylinositol 3-kinase (PI3K) pathway supports growth of many tumors including those of breast, lung, and prostate. Resistance of breast cancer cells to targeted chemotherapies including tyrosine kinase inhibitors (TKI) has been linked to persistent PI3K activity, which may in part be due to increased membrane expression of… CONTINUE READING