RGS proteins maintain robustness of GPCR-GIRK coupling by selective stimulation of the G protein subunit Gαo.

Abstract

Termination of heterotrimeric guanine nucleotide-binding protein (G protein) signaling downstream of activated G protein-coupled receptors (GPCRs) is accelerated by regulator of G protein signaling (RGS) proteins, which act as guanosine triphosphatase (GTPase)-activating proteins (GAPs). Using a Xenopus oocyte expression system, we found that although RGS… (More)
DOI: 10.1126/scisignal.2002202

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