RGS proteins determine signaling specificity of Gq-coupled receptors.

  title={RGS proteins determine signaling specificity of Gq-coupled receptors.},
  author={Xiaohong Xu and Wei-sen Zeng and Serguei Popov and David M. Berman and Isabelle Davignon and Kai Yu and David Yowe and Stefan Offermanns and Shmuel Muallem and Thomas M. Wilkie},
  journal={The Journal of biological chemistry},
  volume={274 6},
Regulators of G protein signaling (RGS) proteins accelerate GTP hydrolysis by Galpha subunits, thereby attenuating signaling. RGS4 is a GTPase-activating protein for Gi and Gq class alpha subunits. In the present study, we used knockouts of Gq class genes in mice to evaluate the potency and selectivity of RGS4 in modulating Ca2+ signaling transduced by different Gq-coupled receptors. RGS4 inhibited phospholipase C activity and Ca2+ signaling in a receptor-selective manner in both permeabilized… CONTINUE READING


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