RGS proteins: G protein-coupled receptors meet their match.

Abstract

Many drugs act on receptors coupled to heterotrimeric G proteins. Historically, drug discovery has focused on agents that bind to the receptors and either stimulate or inhibit the receptor-initiated signal. This is an approach that is both direct and logical, and has proven extremely fruitful in the past. However, as our understanding of G-protein signaling… (More)

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Cite this paper

@article{Chasse2003RGSPG, title={RGS proteins: G protein-coupled receptors meet their match.}, author={Scott A Chasse and Henrik G. Dohlman}, journal={Assay and drug development technologies}, year={2003}, volume={1 2}, pages={357-64} }