RGS protein specificity towards Gq- and Gi/o-mediated ERK 1/2 and Akt activation, in vitro.

  title={RGS protein specificity towards Gq- and Gi/o-mediated ERK 1/2 and Akt activation, in vitro.},
  author={Thomas Anger and Nils Klintworth and Christian Stumpf and Werner Guenther Daniel and Ulrike Mende and Christoph D. Garlichs},
  journal={Journal of biochemistry and molecular biology},
  volume={40 6},
Extracellular Regulated Kinases (ERK) and Protein Kinase B (Akt) are intermediaries in relaying extracellular growth signals to intracellular targets. Each pathway can become activated upon stimulation of G protein-coupled receptors mediated by G(q) and G(i/o) proteins subjected to regulation by RGS proteins. The goal of the study was to delineate the specificity in which cardiac RGS proteins modulate G(q)and G(i/o)-induced ERK and Akt phosphorylation. To isolate G(q)- and G(i/o)-mediated… CONTINUE READING


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