RGS mRNA Expression in Rat Striatum

  title={RGS mRNA Expression in Rat Striatum},
  author={S. A. Burchett and M. Bannon and J. Granneman},
  journal={Journal of Neurochemistry},
  • S. A. Burchett, M. Bannon, J. Granneman
  • Published 1999
  • Chemistry, Medicine
  • Journal of Neurochemistry
  • Abstract: Single injections of cocaine, amphetamine, or methamphetamine increased RGS2 mRNA levels in rat striatum by two‐ to fourfold. The D1 dopamine receptor‐selective antagonist SCH‐23390 had no effect by itself but strongly attenuated RGS2 mRNA induction by amphetamine. In contrast, the D2 receptor‐selective antagonist raclopride induced RGS2 mRNA when administered alone and greatly enhanced stimulation by amphetamine. To examine the effects of repeated amphetamine on RGS2 expression, rats… CONTINUE READING
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