RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis

  title={RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis},
  author={Rieko Muramatsu and Takekazu Kubo and Masahiro Mori and Yuka Nakamura and Yuki Fujita and Tsugio Akutsu and Tatsusada Okuno and Junko Taniguchi and Atsushi Kumanogoh and Mari Yoshida and Hideki Mochizuki and Satoshi Kuwabara and Toshihide Yamashita},
  journal={Nature Medicine},
In multiple sclerosis, activated CD4+ T cells initiate an immune response in the brain and spinal cord, resulting in demyelination, degeneration and progressive paralysis. Repulsive guidance molecule-a (RGMa) is an axon guidance molecule that has a role in the visual system and in neural tube closure. Our study shows that RGMa is expressed in bone marrow–derived dendritic cells (BMDCs) and that CD4+ T cells express neogenin, a receptor for RGMa. Binding of RGMa to CD4+ T cells led to activation… CONTINUE READING


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