RGD-tethered Silk Substrate Stimulates the Differentiation of Human Tendon Cells

@article{Kardestuncer2006RGDtetheredSS,
  title={RGD-tethered Silk Substrate Stimulates the Differentiation of Human Tendon Cells},
  author={Tarik Kardestuncer and Mary Beth Mccarthy and Vassilis Karageorgiou and David L. Kaplan and Gloria A. Gronowicz},
  journal={Clinical Orthopaedics and Related Research},
  year={2006},
  volume={448},
  pages={234-239}
}
Tendon reconstruction surgery often requires healing of the tendon to bone. The development of a more rapid and strong interaction at the tendon to bone interface would be invaluable to patients having orthopaedic surgery. Therefore, our rationale was to modify sutures so that they would be anabolic for tendon to bone healing. It has been shown that silk stimulates bone formation in osteoblast cultures. In the current study, we tested the ability of silk and silk-RGD (arginine-glycine-aspartic… 
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90 Citations

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This study represents a characterization of tenocyte-like cells from the human rotator cuff as close as possible and allows further studies to improve production of tendon matrix and osteofibroblastic integration at the tendon-bone unit following tendon repair.

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The ease of multilayered construct fabrication, enhanced biomechanical properties, along with uniformity of cell distribution confirmed the possibility for the incorporation and segregation of different cell types within distinct layers for the regeneration of complex tissues, such as skin, or central nervous system dura mater.
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