RGD-tethered Silk Substrate Stimulates the Differentiation of Human Tendon Cells

  title={RGD-tethered Silk Substrate Stimulates the Differentiation of Human Tendon Cells},
  author={T. Kardestuncer and M. Mccarthy and V. Karageorgiou and D. Kaplan and G. Gronowicz},
  journal={Clinical Orthopaedics and Related Research},
  • T. Kardestuncer, M. Mccarthy, +2 authors G. Gronowicz
  • Published 2006
  • Medicine
  • Clinical Orthopaedics and Related Research
  • Tendon reconstruction surgery often requires healing of the tendon to bone. The development of a more rapid and strong interaction at the tendon to bone interface would be invaluable to patients having orthopaedic surgery. Therefore, our rationale was to modify sutures so that they would be anabolic for tendon to bone healing. It has been shown that silk stimulates bone formation in osteoblast cultures. In the current study, we tested the ability of silk and silk-RGD (arginine-glycine-aspartic… CONTINUE READING
    84 Citations
    Stem cell-based tissue engineering with silk biomaterials.
    • 782
    • PDF
    Silk as a Biomaterial.
    • 1,663
    Biologic enhancement of a common arthroscopic suture.
    • 7
    Characterization of tendon cell cultures of the human rotator cuff.
    • 65
    • PDF
    Albumin-Coated Bioactive Suture for Cell Transplantation
    • 20


    Functionalized silk-based biomaterials for bone formation.
    • 726
    Use of Recombinant Human Bone Morphogenetic Protein-2 to Enhance Tendon Healing in a Bone Tunnel
    • 327
    Human bone marrow stromal cell and ligament fibroblast responses on RGD-modified silk fibers.
    • 295
    Engineering bone-like tissue in vitro using human bone marrow stem cells and silk scaffolds.
    • 312
    • PDF
    Use of mesenchymal stem cells in a collagen matrix for achilles tendon repair
    • 785
    • PDF
    Enhancement of tendon graft osteointegration using mesenchymal stem cells in a rabbit model of anterior cruciate ligament reconstruction.
    • J. Lim, J. Hui, L. Li, A. Thambyah, J. Goh, Eng-Hin Lee
    • Medicine
    • Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
    • 2004
    • 250
    • PDF
    Bone morphogenetic protein-2 decorated silk fibroin films induce osteogenic differentiation of human bone marrow stromal cells.
    • 280
    Augmentation of Tendon Healing in an Intraarticular Bone Tunnel with Use of a Bone Growth Factor *
    • 172
    Attachment and spreading of fibroblasts on an RGD peptide-modified injectable hyaluronan hydrogel.
    • 246
    Tendon-healing in a bone tunnel. A biomechanical and histological study in the dog.
    • 862