RGD-mediated adhesion of porcine granulosa cells modulates their differentiation response to FSH in vitro.

@article{Goxe1995RGDmediatedAO,
  title={RGD-mediated adhesion of porcine granulosa cells modulates their differentiation response to FSH in vitro.},
  author={B. Goxe and Jacques E. Flechon and S Delasalle and Roland Salesse},
  journal={Biology of the cell},
  year={1995},
  volume={83 2-3},
  pages={169-77}
}
Porcine granulosa cells cultured in serum-free medium undergo metabolic and morphologic changes after follicle stimulating hormone (FSH) stimulation. Under these conditions, granulosa cells differentiate and tend to round up and their links with the plastic support are reduced. Coating of culture substratum with PepTite-2000, an integrin-binding synthetic peptide containing RGD (Arg-Gly-Asp) sequences enhanced the plating of granulosa cells. Whether the peptide be present or not, cells… CONTINUE READING