RGD-containing molecules induce macropinocytosis in ascidian hyaline amoebocytes.

  title={RGD-containing molecules induce macropinocytosis in ascidian hyaline amoebocytes.},
  author={Loriano Ballarin and Paolo Burighel},
  journal={Journal of invertebrate pathology},
  volume={91 2},
Phagocytes of the compound ascidian Botryllus schlosseri are capable of constitutive macropinocytosis (MP) at sites of membrane ruffling along the leading edge. This gives rise to the formation of initially irregular vesicles which then move to the inside of the cells and acquire a more regular morphology. Both phagocyte spreading and MP are enhanced by the recognition of molecules containing the sequence Arg-Gly-Asp (RGD): this suggests that, as in mammals, integrin activation is involved in… CONTINUE READING