RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature.
@article{Temming2005RGDbasedSF, title={RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature.}, author={K. Temming and R. Schiffelers and G. Molema and R. J. Kok}, journal={Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy}, year={2005}, volume={8 6}, pages={ 381-402 } }
During the past decade, RGD-peptides have become a popular tool for the targeting of drugs and imaging agents to alphavbeta3-integrin expressing tumour vasculature. RGD-peptides have been introduced by recombinant means into therapeutic proteins and viruses. Chemical means have been applied to couple RGD-peptides and RGD-mimetics to liposomes, polymers, peptides, small molecule drugs and radiotracers. Some of these products show impressive results in preclinical animal models and a RGD targeted… CONTINUE READING
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