RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature.

@article{Temming2005RGDbasedSF,
  title={RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature.},
  author={K. Temming and R. Schiffelers and G. Molema and R. J. Kok},
  journal={Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy},
  year={2005},
  volume={8 6},
  pages={
          381-402
        }
}
  • K. Temming, R. Schiffelers, +1 author R. J. Kok
  • Published 2005
  • Biology, Medicine
  • Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
  • During the past decade, RGD-peptides have become a popular tool for the targeting of drugs and imaging agents to alphavbeta3-integrin expressing tumour vasculature. RGD-peptides have been introduced by recombinant means into therapeutic proteins and viruses. Chemical means have been applied to couple RGD-peptides and RGD-mimetics to liposomes, polymers, peptides, small molecule drugs and radiotracers. Some of these products show impressive results in preclinical animal models and a RGD targeted… CONTINUE READING
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